The Cherry-and-Whites, who last lost a home Premiership tie way back in September 2001, found themselves trailing on three occasions as the normally metronomic boot of Ludovic Mercier malfunctioned, the Frenchman missing four shots at goal.
But with the kicking duties going to Paul, the former Rugby League star was able to make a match-winning contribution, kicking penalties in the 55th and 79th minute before rounding off the afternoon with a superb try.
The early indications were that it would be business as usual for Gloucester as Mercier opened his side’s account with a penalty in the fourth minute, but Wasps were undaunted by the challenge of taking on Gloucester on their home patch, Alex King kicking two penalties to put his side into the lead.
But Gloucester were able to retake the lead in injury time, second row Mark Cornwell burrowing under a heap of bodies to score his side’s first try.
After the break, Wasps hit back, centre Fraser Waters charging down a clearance kick by Marcel Garvey to grab a try.
Cornwell scored a second try in the 53rd minute, but found themselves once again in arrears as King landed a penalty.
But it was to be Gloucester’s day as Paul kicked two penalties before diving over for an injury-time try to seal the win, although Wasps did gain some consolation in injury time, gaining a bonus point through a further penalty goal by King.
Gloucester: Tries: Mark Cornwell (2), Henry PaulPens: Ludovic Mercier, Henry Paul (2)
London Wasps:Try: Fraser WatersCons: Alex King (4)