Saracens have won their last three matches in Aviva Premiership Rugby, against Sale, Newcastle and Bath, since their 23-31 reversal at Gloucester on 17 February. Saracens have played nine previous Premiership Rugby matches at Wembley Stadium winning seven, drawing one (Leicester 2012) and losing one (Harlequins 2012).
Harlequins have won their last two Aviva Premiership Rugby matches at Gloucester and at home to Newcastle, but have not won three in a row in the tournament since May 2014. Harlequins have visited Wembley Stadium on five previous occasions, all against Saracens but only winning once: 24-19 on 31 March 2012.
Saracens had won eight successive matches against Harlequins in all tournaments but since have lost two of the last three. Quins were victorious 17-10 at The Stoop in round 4 and have not achieved a Premiership Rugby double over Saracens since season 2008/09.
Wembley Stadium, 4.30pm, Live on BT Sport
Referee: Ian Tempest (30th Premiership game).
Assistant Referees: Tim Wigglesworth & Roy Maybank.
TMO: David Sainsbury.