The last four encounters between the two teams have all been won by the home side on the day.
Saracens beat Racing Metro in Paris on Friday but have not won back to back matches since early October. Saracens have won all three previous Premiership matches they have played at Wembley Stadium but lost 23-25 there to Leinster in the European Cup in October.
London Wasps have won their last six matches in all competitions since their 6-29 reversal at Exeter in the Anglo-Welsh Cup on 6 November. Wasps have won five of their last six games in Aviva Premiership Rugby.
Referee: Tim Wigglesworth (27th Premiership game)
Live on SkySports HD.