Leicester have won their last four encounters against Saracens, whilst Sarries have never won at Welford Road in 32 previous visits in all competitions.
Leicester Tigers have already secured top spot in the Guinness Premiership and a playoff spot for a sixth successive season. The Tigers are bidding to go through an entire Premiership campaign unbeaten at home for the fifth time.
Saracens will meet Northampton in the Guinness Premiership semi-finals, but need to win this game to give themselves any chance of that match being played on home soil. Sarries have already won five games on the road this season, including their last two trips, to Sale and Northampton.