London Irish won 18-12 when the two clubs met at Madejski Stadium in round 6, and are seeking a second Premiership double over the current champions having won home and away in season 2002-03.
Leicester Tigers’ 29 game run during which they have picked up at least one league point from every match came to an end at Northampton on Saturday.
The only visiting side to come away from Welford Road with a league point in the Guinness Premiership this season was Worcester in their 14-19 loss on 3 October.
London Irish’s seven game winless run in all competitions ended on Sunday with their 29-14 eclipsing of Harlequins at Madejski Stadium.
The Exiles are the second best away team in the Guinness Premiership having picked up 19 league points on their travels this season.