Harlequins have slipped to successive defeats, at home to Leicester and away at Northampton. The Londoners have not lost successive Aviva Premiership Rugby encounters at Twickenham Stoop since September 2013.
Sale Sharks achieved their highest Premiership Rugby score since they beat Worcester in 2004 in overcoming Gloucester 57-10 last Friday.
The Sharks have lost their last nine away games in the tournament whilst their only victory on the road since round 22 in 2015/16 was at Bristol last October.
The last four meetings between the two clubs in Premiership Rugby have all been won by the home side on the day, although Sale did win at Twickenham Stoop last season in the Anglo-Welsh Cup in February. The Sharks only success at the venue in Premiership Rugby since May 2008 came in November 2014.
Twickenham Stoop, 7.45pm – Live on BT Sport
Referee: Matthew Carley (64th Premiership game).
Assistant Referees: Adam Leal & Wayne Falla.
TMO: Stuart Terheege.
Citing Officer: Buster White.