Worcester Warriors failed to obtain an Aviva Premiership Rugby victory in the first seven rounds but since have won four of the last seven.
The Warriors have won twice at home in the tournament this season, against Northampton in round 8 and London Irish in round 11.
Gloucester Rugby’s last five matches in Aviva Premiership Rugby have all been won by the home side on the day.
Gloucester’s two away wins since March in Premiership Rugby came in successive trips, to Bath in October and Newcastle in November.
Gloucester have lost just once to Warriors since May 2014: 20-28 at Sixways in March 2016.
Worcester Warriors v Gloucester Rugby (Sixways, 3pm)
Referee: Tom Foley (48th Premiership game).
Assistant Referees: Jack Makepeace & Paul Dix. TMO: Geoff Warren.
Citing Officer: Dave Guyan with Jay Curts.