Sale Sharks only loss in the last six rounds of Aviva Premiership Rugby was 16-20 at Gloucester on 30 December.
The Sharks have lost just once at home since round 2in the tournament: 6-10 to Exeter at the end of October.
Saracens have won their last four Aviva Premiership Rugby fixtures since their 19-20 defeat to Harlequins at Twickenham Stoop on 3 December.
Saracens have won their last two away games in Premiership Rugby but have not won three in a row on their travels in the competition in the same season since December 2015.
Saracens have lost only one of their last thirteen clashes with Sale in Premiership Rugby: 10-14 at AJ Bell Stadium in February 2015.
Sale beat Saracens 29-22 in the Anglo-Welsh Cup at Salford in November.
Sale Sharks v Saracens (AJ Bell Stadium, 7.45pm) Live on BT Sport
Referee: Luke Pearce (71st Premiership game).
Assistant Referees: Adam Leal & Wayne Falla. TMO: Stuart Terheege.
Citing Officer: Pete Larter.