Leicester Tigers only victory in the last six rounds of Aviva Premiership Rugby was 19-15 at home to London Irish on 6 January.
The Tigers have lost three Premiership Rugby matches at Welford Road this season, against Bath in round 1, Worcester in round 9 and Saracens in round 11.
Harlequins have recorded just two wins in the last seven rounds of Aviva Premiership Rugby, 20-19 at home to Saracens in round 10 and 50-21 over Northampton in the ‘Big Game’ at Twickenham on 30 December.
‘Quins only away win in Premiership Rugby since last March was 24-21 against Wasps in Coventry in September.
Leicester have won their last three matches against Harlequins since the Londoner’s 25-19 victory at Twickenham Stoop in February 2016. ‘Quins most recent victory at Welford Road was 23-16 in November 2013.
Leicester Tigers v Harlequins (Welford Road, 3pm) Live on BT Sport
Referee: Wayne Barnes (194th Premiership game).
Assistant Referees: Luke Pearce & Hamish Smales. TMO: David Grashoff.
Citing Officer: Shaun Gallagher.