Harlequins have won their last three encounters with Saracens, but Sarries have been victorious in two of their last three visits to the Twickenham Stoop.
Harlequins have recorded just one victory from their last six matches in all competitions: 31-12 at home to Newcastle Falcons in the Guinness Premiership on 25 April.
Saracens have begun the 2009/10 campaign with back to back victories but have not started a Premiership season with three straight wins since way back in 1998/99. Brendan Venter has won his last four games in the Premiership as a head coach, having also won his last two matches in charge at London Irish at the end of the 2002/03 season.
Referee: Chris White (163rd Premiership game)