After contrasting results last weekend Wasps and Saracens go head-to-head at Allianz Park on Sunday with referee Ian Tempest set to take charge.
It will be Tempest’s 36th game as a referee at this level while Paul Dix and Nigel Carrick will be operating as his assistant referees for the weekend’s clash.
Sean Davey will be on hand as the TMO with Paul Hull as Citing Commissioner in what is expected to be another huge game of Aviva Premiership Rugby.
The weekend’s action begins on BT Sport when Harlequins welcome Sale to the Twickenham Stoop where Matthew Carley will be the man in the middle.
There are four matches kicking off at 3pm on Saturday with the experienced Wayne Barnes taking charge of Gloucester Rugby against Northampton Saints at Kingsholm.
Barnes will be one game away from Chris White’s record of 190 Premiership matches at the end of the weekend, a record he could match at the end of this month.
Elsewhere, Luke Pearce has the whistle for Bath Rugby’s match against Worcester Warriors while Andrew Jackson takes control of Newcastle Falcons’ trip to Exeter Chiefs.
And finally, JP Doyle will be in front of the BT Sport cameras at the Madejski Stadium, as Leicester Tigers meet London Irish in Reading.
Friday 6 October
Harlequins v Sale
Twickenham Stoop, 7:45pm – Live on BT Sport
Referee: Matthew Carley (64th Premiership game)
Assistant referees: Adam Leal & Wayne Falla
TMO: Stuart Terheege
Citing Commissioner: Buster White
Saturday 7 October
Bath Rugby v Worcester Warriors
The Rec, 3pm
Referee: Luke Pearce (65th Premiership game)
Assistant referees: Christophe Ridley & Simon McConnell
TMO: Graham Hughes
Citing Commissioner: Andy Blyth
Exeter Chiefs v Newcastle Falcons
Sandy Park, 3pm
Referee: Andrew Jackson (8th Premiership game)
Assistant referees: Jack Makepeace & Philip Watters
TMO: Keith Lewis
Citing Commissioner: Pete Larter
Gloucester Rugby v Northampton Saints
Referee: Wayne Barnes (189th Premiership game)
Assistant referees: Hamish Smales & Jonathan Healy
TMO: Geoffrey Warren
Citing Commissioner: Wade Dooley
London Irish v Leicester Tigers
Madejski Stadium, 3pm – Live on BT Sport
Referee: John-Paul Doyle (138th Premiership game)
Assistant referees: Anthony Woodthorpe & Matthew O’Grady
TMO: David Rose
Citing Commissioner: John Byett
Sunday 8 October
Saracens v Wasps
Allianz Park, 3pm – Live on BT Sport
Referee: Ian Tempest (36th Premiership game)
Assistant referees: Paul Dix & Nigel Carrick
TMO: Sean Davey
Citing Commissioner: Paul Hull