Dallaglio will once again captain the side, while Mark Lock drops out of the team. Lewsey will start on the right wing ahead of Shane Rosier, with the latter also dropping out.
Also returning to the side are Craig Dowd and Jonny O' Connor, who were also given a rest last week. Dowd, who was barred from playing for the New Zealand Barbarians in Saturday's match against England, replaces Tim Payne at prop, while O'Connor starts at No.6, with Paul Volley moving to the other side of the scrum to fill in for Joe Worsley.
Worsley will be turning out for England on the weekend.
The match will also herald the return of hooker Phil Greening, who has been struggling to overcome a toe injury and Sevens star Paul Sampson. Greening replaces former Samoa hooker Trevor Leota in the side.
On the bench former England winger Paul Sampson will be making his first appearance for the Wasps this season since suffering a knee injury during last season’s IRB Dubai Sevens. Sampson was then loaned out to Bath for three weeks during November before returning to Wasps.
London Wasps: 15 Mark Van Gisbergen, 14 Josh Lewsey, 13 Fraser Waters, 12 Mark Denney, 11 Tom Voyce, 10 Alex King, 9 Rob Howley, 8 Lawrence Dallaglio, 7 Jonny O'Connor, 6 Paul Volley, 5 Richard Birkett, 4 Martin Purdy, 3 Will Green, 2 Phil Greening, 1 Craig Dowd.Replacements: 16 Trevor Leota, 17 Tim Payne, 18 Ian Clarke, 19 George Skivington, 20 Peter Richards, 21 Ayoola Erinle, 22 Paul Sampson.