Redpath replaces fellow scrum-half Nich Walshe, who drops down to the bench, in the only change made to the backline.
Up front, White starts on the side of the scrum ahead of Alex Sanderson, while Stuart Turner, Andy Titterrell and Kevin Yates replace Barry Stewart, Matt Cairns and Andrew Sheridan respectively in the front row.
While the Sharks are coming off a big win against Saracens last weekend, Mallinder is looking to reverse the loss they suffered to the Exiles the last time the two teams met.
"We lost by two points the last time we met, and we will be looking to turn that around," said Mallinder.
Sale: 15 Vaughan Going, 14 Mark Cueto, 13 Graeme Bond, 12 Braam van Straaten, 11 Chris Mayor, 10 Charlie Hodgson, 9 Bryan Redpath (captain), 8 Chris Jones, 7 Stuart Pinkerton, 6 Jason White, 5 Dean Schofield, 4 Iain Fullarton, 3 Stuart Turner, 2 Andy Titterrell, 1 Kevin Yates.Replacements: 16 Paul Devlin, 17 Jos Baxendell, 18 Nich Walshe, 19 Matt Cairns, 20 Barry Stewart, 21 Alex Sanderson, 22 Magnus Lund.