Catt jumps straight into the starting line-up at fly half with the Zurich Premiership's top points scorer Olly Barkley moving back to inside centre.
Meanwhile, centre Tindall starts from the bench where he will be joined by lock Danny Grewcock who has fully recovered from a broken bone in his hand. Iain Balshaw is rested, whilst Ireland international Kevin Maggs is recovering from a bout of flu.
For the first time this season there is a change in the pack due to Michael Lipman's three-week ban for illegal use of the boot. England under 21 international James Scaysbrook starts at openside.
Speaking of the return of the England World Cup contingent, Head Coach John Connolly said: "It is good to have them back. They are keen to get back into the action and have fitted in well in training this week. Their challenge is to set an example that befits their status of World Cup winners."
Bath Rugby: 15 Matt Perry, 14 Wylie Human, 13 Andrew Higgins, 12 Olly Barkley, 10 Mike Catt, 9 Martyn Wood, 8 Zak Feaunati, 7 James Scaysbrook, 6 Andy Beattie, 5 Rob Fidler, 4 Steve Borthwick, 3 Duncan Bell, 2 Jonathan Humphreys (capt), 1 David FlatmanReplacements: 16 Hentie Martens, 17 Lee Mears, 18 Matt Stevens, 19 Robbie Kydd, 20 Mike Tindall, 21 Scott Gray, 22 Danny Grewcock.
Kick-off: Saturday @ 15:00 GMT