Rob Hoadley, having recovered from a viral infection, starts in place of Nils Mordt at inside centre as Irish look to record their sixth win in seven games.
Looking forward to this weekend's match, head coach Gary Gold said: "Sale Sharks are a great team that I expect will finish in the top echelons of the Premiership this season. They were a handful for us when we played them four weeks ago. With Charlie Hodgson fully fit and Bryan Redpath back from the World Cup, I am expecting an even more severe test on Sunday."
Players unavailable for selection because of injury are Rob Hardwick (thumb), Kieran Roche (leg), Chris Sheasby (eye) and Ryan Strudwick (leg).
Team: 15 Michael Horak, 14 Paul Sackey, 13 Geoff Appleford, 12 Rob Hoadley, 11, Justin Bishop, 10 Barry Everitt, 9 Darren Edward, 8 Phil Murphy, 7 Kieron Dawson, 6 Declan Danaher 5 Bob Casey, 4 Nick Kennedy, 3 Pierre Durant, 2 Naka Drotske, 1 Neal Hatley (captain) Replacements: 16 Doug Wheatley, 17 Adrian Flavin, 18 Kevin Burke, 19 Paul Gustard, 20 Nick Greenstock, 21 Kevin Barrett, 22 Mark Mapletoft