There are three changes for the side that put away Penzance and Newlyn in the Powergen Cup last week by 30-20.
In the front row, Emiliano Bergamaschi replaces Andy Kershaw. In the second row Simon Raiwalui returns to action swapping with Ben Skirving, while in the back row Ben Russell replaces the injured Ryan Peacey.
On the bench, Robbie Russell makes his first appearance since returning from World Cup action and he is joined by Andy Goode after having the seven stitches removed from his mouth after his collision during the London Irish game.
Sale Sharks would be a difficult test at any time of the season, but struggling Saracens – with 12 men still of out of contention through injury and World Cup duty – will have to remained fully focused for the full 80 minutes if they are to get anything from the game.
"We've made just a couple of changes to the team for Friday night's game," explained Kafer.
"Nothing too dramatic – both Andy Kershaw and Ryan Peacey took knocks during training this week and Simon Raiwalui was being rested on the bench last weekend.
"It's good to have Robbie Russell back from the World Cup as he gives us a few more options up front, and Andy Goode is fully fit after sitting out last weekend's game so he starts on the bench.
"We were hoping that Thomas Castaignède would be ready, but it seems that he's a day or so away right now.
"Over the last few weeks we have begun to move forwards again and it's important that we continue these improvements whoever we're up against.
"Sale are a very good side and threaten from one to fifteen. Their pack is very abrasive and their backs very quick and we'll have our work cut out in defence to contain them.
"We'll go out with an attitude to make the most out a game against a team that are in form. Our away form has been good recently and for this to continue we have to make the most of any opportunities that come our way."
Saracens: 15 Adryan Winnan, 14 Richard Haughton, 13 Ben Johnston, 12 Paul Bailey, 11 Darragh O'Mahony, 10 Nicky Little, 9 Morgan Williams, 8 Taine Randell, 7 Ben Russell, 6 Tony Roques, 5 Kris Chesney, 4 Simon Raiwalui (captain), 3 Ben Broster, 2 Johnny Marsters, 1 Emiliano Bergamaschi.Replacements: 16 Robbie Russell, 17 Steven Sparks, 18 Ben Skirving, 19 Daniel Legge, 20 Dan Kirton, 21 Andy Goode, 22 Denis Cech.