Fly-half Alex King makes his return to competitive rugby via the bench, three months after a knee injury ended his Rugby World Cup hopes.
The 28-year-old was forced to withdraw from England's training camp in August after sustaining the knee injury and was subsequently ruled out of the tournament in Australia.
King has been forced to watch the England action from the other side of the world but has since made a full recovery and is ready to take his place back in the Wasps line-up.
Ironically, his last outing for Wasps was also against Gloucester in the Premiership Final at Twickenham – a game which saw him land the Man of the match award.
The Wasps side features 13 players that were involved in that Final, after playing the majority of this season at No.6, Paul Volley, will move back to his accustomed No.7, with Mark Lock and Ian Clarke completing the back row.
"I'm really glad to be back," said King.
"There is nothing worse as a rugby player than sitting on the sidelines and just watching.
"It's taken a good few months but my knee is healed and I'm ready for Premiership action.
"I'm on the bench and with [incumbent fly-half] Mark Van Gisbergen doing really well, it's going to be tough to get my place back.
"But I'm ready and willing to take up the challenge."
London Wasps: 15 Tom Voyce, 14 Shane Rosier, 13 Fraser Waters, 12 Mark Denney, 11 John Rudd, 10 Mark Van Gisbergen, 9 Rob Howley (captain), 8 Mark Lock, 7 Paul Volley, 6 Ian Clarke, 5 Richard Birkett, 4 Martin Purdy, 3 Will Green, 2 Trevor Leota, 1 Craig Dowd.Replacements: 16 Alex King, 17 Phil Greening, 18 Peter Richards, 19 Jonny O'Connor, 20 John Hart, 21 Peter Scrivener, 22 Tim Payne.
Kick-off: 19.45 GMT