With eleven outside backs missing through the World Cup or injury, the 24-year-old Bulls winger was quickly drafted into the squad to cover for what has developed into an injury crisis amongst the three-quarters.
Chris Malone (foot), Brendon Daniel (back), Tim Brasher (hamstring), Alex Crockett (knee), Lee Best (knee), Spencer Davey (foot) are all injured, whilst Mike Catt, Iain Balshaw, Mike Tindall, Kevin Maggs and Simon Danielli are all in World Cup action.
Another recent loan signing, Paul Sampson from London Wasps, will start the game from the bench.
With Malone out, Olly Barkley moves to fly half for the first time this season, whilst Human's fellow countryman Robbie Fleck moves to inside centre and Andrew Higgins comes off of the wing to his favoured position of outside centre.
However, there is better news in the pack where for the ninth game running, John Connolly has been able to select an unchanged eight.
"Wylie has a proven track record in both the Super Twelve series and the Currie Cup," explained Connolly. "He will slot straight into the side against Gloucester. We have a real injury crisis in the back line, but we can't get hung up on that as injuries are a part of the game."
Gloucester have an incredible home record, but Connolly says that the fact that they have not lost at home this season will not phase his team.
"Gloucester will be the toughest side that we have faced so far this season. They have a very physical pack and some excellent backs with the likes of James Simpson-Daniel and Marcel Garvey. We don't have a problem with Kingholm, I am sure that there will be a special atmosphere at the game."
The match will be the first time that Rob Fidler has returned to Kingsholm since joining Bath Rugby over the summer. The 28-year-old lock says that although he is looking forward to the return, it is not something that has occupied his mind.
"Kingsholm is a great place to play rugby," said Rob. "However, there has not been much banter and to be honest I have not thought about the return. This is a professional sport and I will be going there one hundred percent focused on the job in hand with Bath Rugby."
Bath Rugby: 15 Matt Perry, 14 Wylie Human, 13 Andrew Higgins, 12 Robbie Fleck, 11 Jamie Williams, 10 Olly Barkley, 9 Martyn Wood, 8 Zak Feaunati, 7 Michael Lipman, 6 Andy Beattie, 5 Steve Borthwick, 4 Rob Fidler,3 Duncan Bell, 2 Jonathan Humphreys (capt), 1 David Flatman,Replacements: 16 Ross Blake, 17 Lee Mears, 18 Matt Stevens, 19 Robbie Kydd, 20 Paul Sampson, 21 James Scaysbrook, 22 Scott Gray.
Kick-off: Sat Nov 8, 15:00