In the backline, fly-half Mark Mapletoft, who injured his ankle during last week's game against Rotherham, is replaced by Barry Everitt and Rob Hoadley comes in at inside centre at the expense of Nils Mordt, who drops to the bench.
In the forwards, Declan Danaher starts ahead of Phil Murphy at blindside flanker, with the latter dropping down to the bench.
London Irish: 15 Michael Horak, 14 Paul Sackey, 13 Geoff Appleford, 12 Rob Hoadley, 11 Justin Bishop, 10 Barry Everitt, 9 Darren Edwards, 8 Chris Sheasby, 7 Kieron Dawson, 6 Declan Danaher, 5 Bob Casey, 4 Ryan Strudwick (captain), 3 Rob Hardwick, 2 Naka Drotske, 1 Neal Hatley.Replacements: 16 Pierre Durant, 17 Adrian Flavin, 18 Kieran Roche, 19 Phil Murphy, 20 Nils Mordt, 21 Kevin Barrett, 22 Ross Laidlaw.
Kick-off: 19.45
