In the backline, Paul Bailey returns to continue his early season partnership with Ben Johnston in the centres after the injury to Mark Bartholomeusz last weekend.
In the front row, Emiliano Bergamaschi switches places with Andy Kershaw.
The biggest news takes place on the bench where Morgan Williams, currently down under with Canada, is set to return in time for the kick-off on Saturday after making a mercy dash to help his injury hit club.
Also making an appearance on the bench is young hooker Stuart Philpott, who moves up from the Academy. The 18-year-old has been with the Academy since the age of 14 ,whilst he was at Robert Clack School in Barking. He later joined Campion School and played in the Daily Mail Schools Cup Final at Twickenham last season.
There's no doubting that the Men in Black face a stiff test this weekend and their hosts will be buoyed by both their own and Saracens' recent form, something that Kafer knows only too well.
"We've been forced to make a few changes this week due to our current injury situation," explained Kafer to saracens.com.
"With Mark [Bartholomeusz] ruled out from last weekend Paul [Bailey] comes back into the centres to partner Ben [Johnston] again and up front we're switching Emiliano [Bergamaschi] with Andy [Kershaw].
"On the bench we're pleased to welcome back Morgan [Williams] from the World Cup, I spoke to him this week and explained the situation and he had no worries about heading back early to help us out. We've also brought up Stuart [Philpott] from the Academy, as Joe Ross has just got a little niggle.
"We've done a bit of soul searching this week in the wake of our disappointing performance against Wasps knowing that our trip to Rotherham on Saturday is a big ask for us right now. We know that they have been improving week-by-week and they will be targeting us as their first victory, especially as they are at home.
"We, on the other hand, have been heading in the opposite direction and only through character, pride and determination from one to 15 will we be able to get the result we desire but we are under no illusions as to how hard our task is going to be."
Saracens: 15 Adryan Winnan, 14 Richard Haughton, 13 Paul Bailey, 12 Ben Johnston, 11 Darragh O'Mahony, 10 Andy Goode, 9 Dan Kirton, 8 Taine Randell, 7 Ben Russell, 6 Tony Roques, 5 Kris Chesney, 4 Simon Raiwalui (captain), 3 Ben Broster, 2 Johnny Marsters, 1 Emiliano Bergamaschi.Replacements: 16 Andy Kershaw, 17 Steven Sparks, 18 Stuart Philpott, 19 Ben Skirving, 20 Ryan Peacey, 21 Patrick Phibbs, 22 Morgan Williams.