James Hayter comes in for the injured Tani Fuga at hooker, while props Mike Worsley and Jon Dawson replace Ceri Jones and Laurent Gomez who will both start on the bench.
"We were all very disappointed in our performance last weekend," said Quins boss Mark Evans.
"This game against Sale Sharks gives us an immediate opportunity to put right our errors from last week.
"Sale Sharks were many peoples favourites for the Zurich Premiership this season, and they will provide us with a huge challenge, a challenge that everyone involved with the team is looking forward to.
"We let ourselves and our supporters down against Gloucester, but have worked very hard this week."
NEC Harlequins: 15 Gavin Duffy, 14 Simon Keogh, 13 Mel Deane, 12 Andy Reay, 11 Ugo Monye, 10 Paul Burke, 9 Ben Willis, 8 Tony Diprose, 7 Andre Vos, 6 Pat Sanderson, 5 Jim Evans, 4 Bill Davison, 3 Jon Dawson, 2 James Hayter, 1 Mike Worsley.Replacements: 16 Cameron Dott, 17 Ceri Jones, 18 Laurent Gomez, 19 Roy Winters, 20 Luke Sherriff, 21 Rob Jewell, 22 Andy Dunne.
Kick-off: 15.00 (14.00 GMT)
