In the backline, Peter Richards replaces former Wales captain and scrum-half Rob Howley, while in the forwards, Phil Greening returns in the place of former Samoa hooker Trevor Leota.
Both Howley and Leota have been named on the bench.
In the back row, Johnny O'Connor starts on the openside meaning Paul Volley returns to his favoured blindside position, while Ian Clarke moves to No.8 to replace John Hart, who drops down to the bench.
London Wasps: 15 Tom Voyce, 14 Shane Roiser, 13 Fraser Waters, 12 Mark Denney, 11 John Rudd, 10 Mark van Gisbergen, 9 Peter Richards, 8 Ian Clarke, 7 Jonny O'Connor, 6 Paul Volley, 5 Richard Birkett, 4 Simon Shaw, 3 Craig Dowd (captain), 2 Phil Greening, 1 Tim Payne.Replacements: 16 Rob Howley, 17 Ayoola Erinle, 18 James Haskell, 19 Martin Purdy, 20 John Hart, 21 Alistair McKenzie, 22 Trevor Leota.
Kick-off: 15.00 (14.00 GMT)
