Coach Nigel Melville brings in Mark Cornwell to partner Alex Brown in the second row, with Adam Eustace starts from the bench.
The back-line remains the same with Duncan McRae, who made an impressive debut against Harlequins, set to make his first appearance in front of the Kingsholm faithful.
The 'Cherry and Whites' have won their last two Zurich Premiership fixtures with a 24-3 win at home against Leicester preceding last Saturday’s 16-0 away win at The Stoop.
A win against Leeds on Saturday could see Gloucester close the gap between them and first placed Bath Rugby.
"Leeds have a strong side. We know how good David Rees is, Phil Christophers has good feet and Dan Scarbrough is very powerful. But it's not just about their individuals, they're a good team," wing James Simpson-Daniel told the Gloucester website.
"Teams have been without certain players with the World Cup on, but people have had to step up to the Premiership level. We’ve had good direction from both Nigel and Dean Ryan and we need to continue the hard work that we've been putting in."
Gloucester: 15 Jon Goodridge, 14 Marcel Garvey, 13 Robert Todd, 12 Henry Paul, 11 James Simpson-Daniel, 10 Duncan McRae, 9 Alex Page, 8 James Forrester, 7 Andy Hazell, 6 Jake Boer (captain), 5 Mark Cornwell, 4 Alex Brown, 3 Andy Deacon, 2 Chris Fortey, 1 Paul Johnstone.Replacements: 16 Nick Wood, 17 Steve Brotherstone, 18 Adrian Olver, 19 Adam Eustace, 20 Peter Buxton, 21 Simon Amor,22 Josh Frape.
Kick-off: 15.00 (14.00 GMT)