Best had exploratory surgery on his knee to discover the extent of the damage done to his anterior cruciate ligament during Bath's victory over Saracens last week and it was found that he would have to undergo reconstructive surgery next month.
Connolly has made no changes to the forward for the seventh week running, while hooker Jonathan Humphreys will captain the side once more.
Despite the win against Saracens, Connolly was unhappy with his team's execution last week and will be expecting an improvement against a strong Falcons team.
Bath: 15 Matt Perry, 14 Andrew Higgins, 13 Alex Crockett, 12 Olly Barkley, 11 Brendon Daniel, 10 Chris Malone, 9 Martyn Wood, 8 Zak Feaunati, 7 Michael Lipman, 6 Andy Beattie, 5 Rob Fidler, 4 Steve Borthwick, 3 Duncan Bell, 2 Jonathan Humphreys, 1 David Flatman.Replacements: 16 Ross Blake, 17 Lee Mears, 18 Matt Stevens, 19 Robbie Kydd, 20 Gareth Knox, 21 James Scaysbrook, 22 Scott Gray.
Kick-off: 14.45 BST