The one change to the starting line up sees Joe Shaw come in at fullback in place of Tom May who scored a hat-trick against Gloucester two weeks ago.
But the real talking point is the controversial inclusion of Andrews.
The veteran lock, the most-capped Springbok forward of all-time, received his marching orders last week against Quins for allegedly dropping his knee on Pat Sanderson's head.
The Falcons appealed against the card, and an Rugby Football Union (RFU) disciplinary panel called for more evidence after the match video of the incident concerned proved inconclusive.
Andrews' next hearing has been adjourned until next week, which means he will be allowed to play in the meantime.
The Northampton Saints have made representations to the RFU on the grounds that a player would be unable to play an international game in the same circumstances, but the regulations permit him to play club games.
Meanwhile, England fly-half Dave Walder and flanker Epi Taione return from injury and win berths on the bench.
Newcastle Falcons: 15 Joe Shaw, 14 Michael Stephenson, 13 Jamie Noon, 12 Mark Mayerhofler, 11 Ben Gollings 10 Phil Godman, 9 Hall Charlton, 8 Hugh Vyvyan, 7 Warren Britz, 6 Jon Dunbar, 5 Mark Andrews (captain) 4 Garath Archer, 3 Marius Hurter, 2 Nick Makin, 1 Ian Peel. Replacements: 16 Tom May, 17 Dave Walder, 18 James Grindal, 19 Micky Ward, 20 Matt Thompson, 21 Phil Dowson, 22 Epi Taione. Kick-off: 16.00 (15.00 GMT)