Centre Mark Denney will replace Ayoola Erinle, who picked up a toe injury during this weeks training session and was ruled out.
Former England hooker Phil Greening has recovered from the rib injury that kept him out of the last two games and will start at hooker – Trevor Leota, therefore, moves onto the bench.
The other changes are in the back row, where Peter Scrivener replaces John Hart at No.8 and Jonny O'Connor starts at No.7 after missing last week's loss to Bath because of an ankle injury.
The inclusion of O'Connor means that Paul Volley will switch back to No.6.
On the bench, Michael Roberts comes in as cover for Denney, Mark Lock replaces James Haskell and Martin Purdy replaces George Skivington.
London Wasps: 15 Tom Voyce, 14 Shane Roiser, 13 Fraser Waters, 12 Mark Denney, 11 John Rudd, 10 Mark Van Gisbergen, 9 Rob Howley (captain), 8 Peter Scrivener, 7 Jonny O'Connor, 6 Paul Volley, 5 Richard Birkett, 4 Simon Shaw, 3 Craig Dowd, 2 Phil Greening, 1 Tim Payne.Replacements: 16 Peter Richards, 17 Michael Roberts, 18 Ian Clarke, 19 Mark Lock, 20 Martin Purdy, 21 Alistair McKenzie, 22 Trevor Leota.
Kick-off: 19.45 BST (18.45 GMT)