The double RL World Cup winner has been named on the bench as one of two changes to the side that defeated Sale Sharks by 14-9 at Edgeley Park last Friday.
"It is a challenge," said Brasher, a veteran of 21 State of Origin matches.
"Life is full of challenges and we all thrive on them and if the chance comes then I will certainly grab it with both hands. I have been keeping myself fit and feel extremely motivated and want to do well for Bath."
Brasher arrived at Bath only at the beginning of the week to help out coach Brian Smith in lending his vast experience to training. However, with Alex Crockett (knee), Spencer Davey (foot) and Andrew Higgins (hamstring) all unavailable, Brasher has been registered as a player.
The only other change sees scrum-half Hentie Martens replace Ross Blake on the bench, with Martyn Wood starting in the No.9 jersey.
Head coach John Connolly has no doubt that Sunday's game will be Bath's biggest test so far this season.
"Wasps are a very good side," he said.
"They are the champions and so far this season have been unlucky not to be three wins from three as if you look at the stats they have completely dominated their games. We are hopeful of a win, but we will need to perform as we did in the first half up at Leeds."
Bath: 15 Matt Perry, 14 Lee Best, 13 Jamie Williams, 12 Olly Barkley, 11 Brendon Daniel, 10 Chris Malone, 9 Martyn Wood, 8 Zak Feaunati,7 Michael Lipman, 6 Andy Beattie, 5 Rob Fidler, 4 Steve Borthwick, 3 Duncan Bell, 2 Jonathan Humphreys, 1 David Flatman.Replacements: 16 Hentie Martens, 17 Lee Mears, 18 Matt Stevens, 19 Robbie Kydd, 20 Tim Brasher, 21 James Scaybrook, 22 Scott Gray.
Kick-off: 14.00 BST (13.00 GMT)