The centre had started Sarries' opening win against the Newcastle Falcons on the bench after struggling with a knock sustained during training.
His replacement Paul Bailey played well and retained his spot for last week's draw with Leicester, but he is now nursing a slight dead leg and is named as a replacements.
The other change in the starting line-up is at scrum-half where Dan Kirton moves up now that Morgan Williams has headed off to join Canada's World Cup squad. His place on the bench is taken by Patrick Phibbs, the short-loan signing who flew in from Australia last week.
The only other change to the side sees hooker James Parkes return to the 22 after proving his fitness and he dislodges Aston Croall from the bench.
The rest of the side is unchanged with Kafer again rewarding his performers for a decent start to the new season.
Coach Kafer said: "I think that we have continued in our improvement in recent weeks and this weekend sees us undergo another tough examination of how far we have come. I know the players are looking forward to the game on Saturday and we will get a chance to put some of our work into practice again.
"Gloucester are a very physical side, they're aggressive and will be looking to take us on both up front and in midfield and get in our faces, something that they do very well and at Kingsholm in particular.
"We'll need to be able to cope with that type of pressure and we have worked on this a little in training this week although, again, we have spent a lot of time on our defence and the basics."
Saracens: 15 Thomas Castaignede, 14 Richard Haughton, 13 Kevin Sorrell, 12 Ben Johnston, 11 Nathan McAvoy, 10 Andy Goode, 9 Dan Kirton, 8 Taine Randell, 7, Ryan Peacey, 6 Tony Roques, 5 Kris Chesney, 4 Simon Raiwalui (captain), 3 Emiliano Bergamaschi, 2 Joe Ross, 1 Steven Sparks.Replacements: 16 Andy Kershaw, 17 James Parkes, 18 Ben Broster, 19 Ben Skirving, 20 Patrick Phibbs, 21 Paul Bailey, 22 Adryan Winnan.
Kick-off: 14.45 (13.45 GMT)