The recently-signed Pez arrived last week after he was dumped from the Italy World Cup squad by coach John Kirwan, but failed to force his way into the Tigers starting XV for their 19-19 draw against Saracens, coming on from the bench in the latter stages.
Pez replaces Sam Vesty, who drops down to the bench, in one of three changes to the side.
American international Dan Lyle has left to join the Eagles' World Cup squad after a rib injury prevented him playing last week, and is replaced by Adam Balding. In the final change James Hamilton takes over from Brett Deacon at lock.
Leicester Tigers: 15 Tim Stimpson, 14 Ollie Smith, 13 Leon Lloyd, 12 Daryl Gibson, 11 John Holtby, 10 Ramiro Pez, 9 Harry Ellis, 8 Adam Balding, 7 Josh Kronfeld, 6 Will Johnson, 5 Louis Deacon, 4 James Hamilton, 3 Ricky Nebbett, 2 George Chuter, 1 Graham Rowntree.Replacements: 16 Jim Richards, 17 Darren Morris, 18 Tom Ryder, 19 Henry Tuilagi, 20 Austin Healey, 21 Sam Vesty, 22 Will Skinner.
Kick-off: 19.45 BST (18.45 GMT)