Greenstock comes in for Nils Mordt whilst also in the side is Barry Everitt at fly-half in place of Mark Mapletoft as London Irish take on former landlords, and unbeaten, Harlequins.
Head Coach, Gary Gold said: “Harlequins have had the best possible start to their season with two wins out of two. They always provide a formidable challenge at The Stoop especially for London Irish!"
"We have struggled to find our best form in our opening games although last Sunday’s performance against Gloucester was encouraging. We are hoping to build on that at the weekend,” he added.
London Irish has announced the following team for its Zurich Premiership away match against NEC Harlequins on Saturday, 27th September, 2003, kick-off at 3.00pm at The Stoop Memorial Ground, Twickenham.
London Irish: 15 Michael Horak, 14 Paul Sackey, 13 Geoff Appleford, 12 Nick Greenstock, 11 Justin Bishop, 10 Barry Everitt, 9 Darren Edwards, 8 Chris Sheasby, 7 Kieron Dawson, 6 Paul Gustard, 5 Bob Casey, 4 Ryan Strudwick (captain), 3 Rob Hardwick, 2 Naka Drotské, 1 Neal Hatley.Replacements: 16 Pierre Durant, 17 Adrian Flavin, 18 Kieran Roche, 19 Phil Murphy, 20 Nils Mordt, 21 Kevin Barrett, 22 Mark Mapletoft.
Kick-off: 15.00 BST (14.00 GMT)