Irish fullback Gavin Duffy gets a place after the impressive youngster's move from Connacht, while England 'A' prop Mike Worsley makes his maiden appearance, starting at loosehead prop following his move from London Irish.
Samoan George Harder is at outside centre after joining from Leeds Tykes, while the side is again led by veteran South African No.8 André Vos.
New Irish fly-half Andy Dunne is only on the bench after signing from Leinster, while his countryman Paul Burke starts in the No.10 shirt.
NEC Harlequins: 15 Gavin Duffy, 14 Simon Keogh, 13 George Harder, 12 Andy Reay, 11 Ugo Monye, 10 Paul Burke, 9 Ben Willis, 8 Tony Diprose, 7 Andre Vos, 6 Pat Sanderson, 5 Simon Miall, 4 Bill Davison, 3 Jon Dawson, 2 Ace Tiatia, 1 Mike Worsley. Replacements: 16 Tani Fuga, 17 Ceri Jones, 18 Jim Evans, 19 Luke Sherriff, 20 Henry Barrett, 21 Andy Dunne, 22 Matt Moore.
Kick-off: 14.45 (13.45 GMT)