Worsley featured in the demolition of Wales in Cardiff last Saturday, scoring a second-half try, and will have been keen to displace regular No.8 Lawrence Dallaglio in the World Cup reckoning with a big performance against the French.
But now that he is out his place goes to Sale Sharks' Alex Sanderson, as coach Clive Woodward continues to rest a number of his front-line stars, including Dallaglio.
Sanderson's ascension to the bench means that Gloucester's Andy Hazell is promoted to the replacement ranks, having fared well for the England 'A' side in the last year.
Revised England: 15 Iain Balshaw (Bath), 14 Josh Lewsey (London Wasps), 13 Ollie Smith (Leicester Tigers), 12 Mike Tindall (Bath), 11 Ben Cohen (Northampton Saints), 10 Paul Grayson (Northampton Saints, vice-captain), 9 Austin Healey (Leicester Tigers), 8 Alex Sanderson (Sale Sharks), 7 Lewis Moody (Leicester Tigers), 6 Martin Corry (Leicester Tigers), 5 Danny Grewcock (Bath), 4 Steve Borthwick (Bath), 3 Julian White (Leicester Tigers), 2 Dorian West (Leicester Tigers, captain), 1 Graham Rowntree (Leicester Tigers).Replacements: 16 Steve Thompson (Northampton Saints), 17 Jason Leonard (NEC Harlequins), 18 Simon Shaw (London Wasps), 19 Andy Hazell (Glouceser), 20 Andy Gomarsall (Gloucester), 21 Dave Walder (Newcastle Falcons), 22 Jamie Noon (Newcastle Falcons).
Kick-off: 21.00 (20.00 BST, 19.00 GMT)Live in the UK on Sky Sports 1