Cueto was taken ill with gastric-flu before last weekend's defeat at Northampton but is improving and has been named in a 23-strong squad that includes Vaughan Going, the talented all-rounder who stepped into his boots at Franklin's Gardens.
One player who will be missing is prop Stuart Turner, a replacement against Northampton, who is suffering from a calf strain. Dan Harris suffered a minor shoulder injury in that game, but has been named in the squad by coach Jim Mallinder, who said he was hopeful that the strong-running centre would be in the starting line-up.
Chris Mayor, the former Wigan Warrior who has played for the England Sevens side this season, has been included in the senior squad for the first time. He plays for the club's Under-21 side at both wing and centre.
Mallinder is looking for an improved performance against the side it is battling with for the right to take on Gloucester in the Zurich Championship Final at Twickenham later in the month.
"Wasps are playing really well at the moment and are enjoying a long, unbeaten run," he said. "They have a very powerful pack and some really exciting players outside, with Rob Howley and Alex King forming an experienced link at halfback.
"Games don't come much bigger than this one and the boys are up for it after last week's disappointing performance. But we will have to be at our very best if we want to gain the upperhand in the bid to reach the Final."
The Sharks (squad): Jason Robinson, Vaughan Going, Mark Cueto, Steve Hanley, Anthony Elliott, Chris Mayor, Graeme Bond, Dan Harris, Jos Baxendell, Nick Walshe, Bryan Redpath, Kevin Yates, Jim Thorp, Barry Stewart, Charl Marais, Andy Titterrell, Dean Schofield, Iain Fullarton, Chris Jones , Pete Anglesea, Stuart Pinkerton, Phil Davies, Magnus Lund.