Tani Fuga starts at hooker, with Ace Tiatia reverting to the back row in place of Roy Winters, who is amongst the replacements.
The other change in the pack sees Bill Davison, who missed Quins' last outing, against Leeds, due to illness, return to the second row in place of Karl Rudzki.
"Saturday is a crucial game for both teams," said NEC Harlequins Chief Executive Mark Evans.
"Leicester are a tremendous side, who have set the highest standards in both the Zurich Premiership and the Heineken Cup. We know that they will be looking to return to winning ways after their defeat to Munster last weekend."
NEC Harlequins: 15 Nathan Williams, 14 Dan Luger, 13 Will Greenwood, 12 Mel Deane, 11 Ben Gollings, 10 Paul Burke, 9 Billy Fulton, 8 Tony Diprose, 7 André Vos (captain), 6 Ace Tiatia, 5 Simon Miall, 4 Bill Davison, 3 Jason Leonard, 2 Tani Fuga, 1 Ceri Jones.Replacements: 16 Roy Winters, 17 Jon Dawson, 18 Jim Evans, 19 Luke Sherriff, 20 Scott Bemand, 21 Viliame Satala, 22 Rob Jewell.
Kick-off: Saturday, 15.00 GMT