While currently bottom of the Premiership, the Falcons have had a decent run of results in recent months and, with games in hand over their nearest rivals, look likely to avoid relegation at the end of the season.
Included in the Falcons' squad are England star Jonny Wilkinson and the most-capped Springbok forward ever, lock Mark Andrews.
Newcastle Falcons (squad, 23):
Forwards: James Isaacson, Ian Peel, Micky Ward, Marius Hurter, Nick Makin, Matt Thompson, Mark Andrews, Stuart Grimes, Craig Hamilton, Epi Taione, Jon Dunbar, Hugh Vyvyan, Phil Dowson.
Backs: James Grindal, Hall Charlton, Jonny Wilkinson, Phil Godman, Mark Mayerhofler, Jamie Noon, Tom May, Michael Stephenson, Joe Shaw, Mark Wilkinson.
Kick-off: Saturday, 15.00 BST