Wasps go into the game having won four of the last five league games and are tied for third with 44 league points together with the Leicester Tigers and Leeds Tykes.
Wasps winger Josh Lewsey has identified England fly-half Johnny Wilkinson as the biggest danger to his side if he is made to play saying: "For me, they have a lot of very talented players and the best No.10 in the world so he will pose a major threat.
"Newcastle haven't had the best of time this season but their away win, at Leeds a few weeks ago, was the turning point in their season and, therefore, will have their tails up."
Lewsey is also very adamant about the rivalry between the two sides, saying: "When the game went professional a lot of the Wasps' players went to Newcastle and settled there," he said, "and so the link between the clubs is big. The rivalry goes back to when we beat them in the '99 Cup Final.
"On a personal front Newcastle, like us, have a lot of young English players, looking for an international spot and these games provide the stage for them to impress the selectors and on Saturday they will be doing that".
Scottish international Kenny Logan said: "This is the working end of the season to get into Europe and clubs like Newcastle, who are near the bottom, will be full of fight. The pressure is on us to move up the league this weekend."
London Wasps: 15 Mark Van Gisbergen, 14 Josh Lewsey, 13 Fraser Waters, 12 Stuart Abbott, 11 John Rudd, 10 Alex King, 9 Rob Howley, 8 Lawrence Dallaglio (captain), 7 Paul Volley, 6 Joe Worsley, 5 Richard Birkett, 4 Simon Shaw, 3 Will Green, 2 Trevor Leota, 1 Craig Dowd.Replacements: 16 Martyn Wood, 17 Phil Greening, 18 Kenny Logan, 19 Mark Denney, 20 Mark Lock, 21 Peter Scrivener, 22 Alistair McKenzie.
Kick-off: 15.00 GMT