Appearing in the one-off match are many current and former members of London Irish who will turn out to raise money for old team-mate Cunningham who was diagnosed with ALS, a form of Motor Neurone Disease, last year.
The list includes Gloucester pair Jake Boer and Robert Todd, Samoa fly-half Steven Bachop and Leeds Tykes back rower Isaac Feaunati.
There will be a full programme of pre and post-match entertainment, including traditional Irish music from the Exiles' house band.
London Irish All-stars XV:
Forwards: Jake Boer, James Cockle, Pierre Durant, Issac Feaunati, Adrian Flavin, Gabriel Fulcher, Simon Halford, Eddie Halvey, Michael Haslett, David Parkes, Kieran Roche, Douglas Wheatley.
Backs: Steven Bachop, Kevin Barrett, Justin Bishop, James Brown, Kieran Campbell, Nambdi Ezulike, Robert Todd, Ben Whetstone, Niall Woods, Jason Wright.
Tickets for the game are on sale via the NEC Harlequins ticket office on 0871 871 8877 or via the internet at www.seatbooker.net/quins/.
Ticket Prices:£15 East and West stands (between the 22 metre lines)£10 North and South stands or standing£5 Concessions
Kick-off: Thursday, March 6, The Stoop, 19.45 (GMT)