Clive Woodward's side, who have held the No.1 spot since the November internationals, are predicted to emerge as sizeable 17-point winners over the fourth ranked French team who won the Grand Slam last year.
Meanwhile, Ireland challenge for Six Nations' honours should get off to a winning start when they travel to Murrayfield with Scotland expected to go down to a 13-point defeat.
Despite their injury problems and off-field political distractions, Wales are tipped to have few problems in Rome when they take on Italy, the lowest ranked team in the competition at 13th, with the computer backing the Dragons to come out comfortable 24 point winners.
Zurich Predictions for 15/16 February:
England v France: England by 17Scotland v Ireland: Ireland by 13Italy v Wales: Wales by 24
Czech Republic v Romania: Romania by 22Portugal v Georgia: Georgia by 10Spain v Russia: Spain by 4