Without their England Senior and A squad players, and opting to rest the rest of their first-choice players, Sharks have included former England Schools winger Aidan Phillipson and lock Paul Arnold who made his senior debut in the defeat of St Helens in the cross-code match at Knowsley Road last week.
Former Stormers and South Africa hooker Charl Marais will also turn out against his old team-mates.
Sharks: 15 Vaughan Going, 14 Chris Mayor, 13 Chris Jones, 12 Mel Deane, 11 Aidan Phillipson, 10 Jos Baxendell, 9 Richard Wigglesworth, 8 Phil Davies, 7 Richard Wilks, 6 Apollo Perelini, 5 Iain Fullarton, 4 Paul Arnold, 3 Stuart Turner, 2 Charl Marais, 1 Jim Thorp.Replacements: TBC.
Kick-off: 19.45 GMT