England international Josh Lewsey returns to the Wasps bench after missing two weeks of action because of a hamstring injury, while Mark Lock replaces Joe Beardshaw on the bench. The latter has a lower back injury.
Midfielder Mark Denney is nursing a slight calf strain and will undergo a fitness test on Friday. If Denney is still troubled by his calf, Ayoola Erinle will replace him on the bench.
"This game is massive for us," said Gatland. "We have targeted Saints, Irish and Newcastle for maximum points."
London Wasps flanker, Paul Volley, speaking about what the game means for the club said: "We've got five home games from now until the end of the season and we're looking at a top-three position.
"It means we've definitely got to win our home games and that starts with Northampton this weekend. The boys have had a week's rest so everyone is up for the game and we just can't wait to get out there and set the record straight after our embarrassment at Franklin's Gardens."
Wasps: 15 Mark Van Gisbergen, 14 John Rudd, 13 Fraser Waters, 12 Stuart Abbott, 11 Kenny Logan, 10 Alex King, 9 Rob Howley, 8 Lawrence Dallaglio (captain), 7 Paul Volley, 6 Joe Worsley, 5 Richard Birkett, 4 Simon Shaw, 3 Will Green, 2 Trevor Leota, 1 Craig Dowd.Replacements: 16 Martyn Wood, 17 Phil Greening, 18 Josh Lewsey, 19 Mark Denney or Ayoola Erinle, 20 Mark Lock, 21 Peter Scrivener, 22 Andy Kershaw.
Kick-off: 15.00 GMT