Scoring four tries to one, Wasps appreciably improved their prospects of qualifying for Europe next season.
While London Irish put up a brave struggle in the first 40 minutes, and even held an 8-7 lead deep into the first half, it was after the break that Wasps turned on the screws and opened a sizeable gap.
With the official clock having already registered more than 30 minutes, Irish were ahead thanks to a try by Paul Sackey and a Barry Everitt penalty. For Wasps Josh Lewsey had scored a try, which was converted by fly-half Alex King.
But then the home team upped the pace and King kicked another penalty to put his team in the lead (10-8), followed by a Mark van Gisbergen try (converted by King) and the half-time scoreboard read 17-8 in Wasps' favour.
It was after the break that things really turned bad for Irish, who are desperately trying to stay clear of the relegation zone.
Despite an early Everitt penalty, which narrowed the gap to 17-11, King kicked two more penalties to open up a sizable gap – 23-11. And in the last 15 minutes Fraser Waters and former All Black Craig Dowd scored to put the match beyond the visitors.
For Wasps:Tries: Waters, Lewsey, Dowd, Van GisbergenCons: King 3Pens: King 3
For London Irish:Try: SackeyPens: Everitt 2