Harlequins recorded a comprehensive 55-17 win over Cavalieri at the Stoop.
Tom Williams opened the scoring before the Quins raced ahead thanks to tries from Ross Chisholm, George Lowe and a penalty try.
Chisholm struck with his second try early in the second half but Cavalieri hit back when Denis Majstorovic touched down.
Williams scored two more tries to bring up his hat-trick while Sam Smith joined him on the scorecard.
Ed Lewis-Pratt scored a late consolation for Cavalieri but it was not enough to overcome Quins' commanding lead.