Harlequins have lost their last three matches at the Twickenham Stoop in all tournaments, against Edinburgh in the European Challenge Cup, Sale in the Anglo-Welsh Cup and Leicester in Aviva Premiership Rugby.
The Leicester defeat spoilt their perfect run of seven home wins out seven in Premiership Rugby this season.
Newcastle Falcons only win in the last four rounds of Aviva Premiership Rugby was 46-31 at home to Northampton Saints in round 15. The Tynesiders’ two away wins in Premiership Rugby this season were at Gloucester in round 4 and Northampton in round 9.
The Falcons have lost just one of their last four fixtures with Harlequins: 25-46 at Twickenham Stoop in this equivalent fixture in round 19 last year.
Newcastle have not been victorious at The Stoop in Premiership Rugby since winning 20-18 in September 2000.
Harlequins v Newcastle Falcons (Twickenham Stoop, 3pm)
Referee: Tom Foley (33rd Premiership game).
Assistant Referees: Hamish Smales & Adam Leal. TMO: Keith Lewis.