Sale Sharks five game winning run in all competitions ended at Saracens on Saturday.
The Sharks have won their last four home games since Bristol beat them by the closest of margins at AJ Bell Stadium on New Year’s Day.
Northampton Saints home win over Worcester Warriors last weekend followed a pair of back-to-back defeats in Premiership Rugby.
The Saints only two victories in their last seven away games in Premiership Rugby were both by a single point, at Worcester in November and at Gloucester in January.
The last eight fixtures between the two clubs in Premiership Rugby have both gone the way of the home side on the day, whilst Northampton’s two victories at AJ Bell Stadium have been in Premiership Rugby in November 2012 and the quarter-final of the European Challenge Cup in April 2014.
Sale Sharks v Northampton Saints (AJ Bell Stadium, 8.15pm)
Referee: Tom Foley (32nd Premiership game).
Assistant Referees: Hamish Smales & Andrew Jackson.
TMO: Keith Lewis.