Harlequins are one of only two sides with a 100 per cent home winning record in Aviva Premiership Rugby this season, however the Londoners have lost their last two matches at Twickenham Stoop in other tournaments, to Edinburgh (Challenge Cup) and to Sale Sharks (Anglo-Welsh).
Leicester Tigers have won their last two Premiership Rugby fixtures, at home to Gloucester and Bristol, but have not been victorious away from home since beating Bristol at Ashton Gate in November.
The Tigers beat Harlequins at Welford Road in round 8 and have not achieved a Premiership Rugby season double over them since 2010/11. Leicester have lost on their last five visits to Twickenham Stoop in all tournaments.
Twickenham Stoop, 7.45pm – Live on BT Sport
Referee: Dean Richards (91st Premiership game).
Assistant Referees: Paul Dix, Nigel Carrick.
TMO: Graham Hughes.