Wasps won 23-3 when the two clubs clashed in round three and perhaps surprisingly have never achieved a Premiership double over the Warriors in the same season.
Worcester Warriors have won just one of their last 15 matches in the Guinness Premiership since September: 13-0 at home to Newcastle on 26 February – a sequence which includes an unprecedented four drawn games.
London Wasps’ last eight matches in all competitions have all been won by the home side on the day, whilst Wasps most recent victory away from home in the Guinness Premiership came on 27 December against Harlequins at Twickenham.
The Londoners have never won in five previous visits to Sixways.
Referee: Dean Richards (35th Premiership game)