Sale have the slight edge in previous Premiership encounters with Warriors, gaining seven wins to five.
Worcester Warriors return to the Premiership after a season playing in and winning the RFU Championship. The Warriors are yet to record a victory in the opening round in six previous Premiership campaigns, whilst their only reversal in their last 18 games last season was to Bedford in the semi-final of the British & Irish Cup.
Sale Sharks have won in round one for the past three seasons, but ended last campaign with an unwanted run of three successive defeats. The Sharks’ have not won away from home in the Premiership at anywhere other than Leeds since their 37-20 victory at Worcester in January 2009.
Referee: David Rose (89th Premiership Game)