Worcester Warriors are without a win in their last eight Guinness Premiership matches, since beating Sale 24-18 at Sixways on 26 September.
London Irish’s three match winning run came to a halt at Northampton on Saturday but the Exiles remain the Guinness Premiership’s best away team, having secured 17 league points from their six trips so far.
Worcester have not beaten London Irish in the Guinness Premiership since 11 September 2005 at Madejski Stadium.
Referee: Chris White (169th Premiership game)
Please note the revised kick-off time of 2pm.