Saracens are unbeaten in their last eleven matches in all competitions, since their 8-30 defeat at Northampton in Aviva Premiership Rugby on 26 November.
Sarries have not lost at Vicarage Road in the Premiership since Exeter were the visitors on 30 October 2010.
Leicester Tigers suffered a first Premiership defeat since 8 October with their 11-19 reversal at Exeter on Saturday evening. Tigers have not lost back to back away trips in the tournament since October 2010.
Saracens have won their last four games against Leicester – their best ever sequence against the Tigers.
Referee: Andrew Small (65th Premiership game)