The top two teams in the Aviva Premiership Rugby table go head to head at Wembley Stadium.
Saracens have won their last two games against Northampton and Sale. Saracens have played in seven previous games at Wembley, losing just once: 23-25 to Leinster in the Heineken Cup on 16 October 2010.
Harlequins’ solo defeat in their last five encounters was 23-29 at Gloucester on 25 February. Quins have not won away from home in 2012, their most recent victory on the road being 11-9 at Exeter on New Year’s Eve.
Saracens have won their last five matches with Harlequins including a 37-18 victory on their only previous clash at Wembley Stadium in April 2010.
Referee: Greg Garner (33rd Premiership game)